Prourokinase (Saruplase) (Last Updated - 4/11/2005)

-NOT yet FDA-approved

-a serine protease thrombolytic
-same profile as Urokinase (Abbokinase)

-1/2-Life:
     -15-20 mins.

-Clearance:
     -hepatic --> caution in hepatic dis.

-Dosing:
     -Loading Dose --> 1000-4500 units/kg IV then
          -4400 units/kg/hr continuous IV

-NOT DOC for coronary thrombolysis in Acute MI's:
     A) expensive (like t-PA)
     B) Lacks fibrin-specificity (like Streptokinase (Streptase)) --> systemic lytic state

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.