Prourokinase (Saruplase) (Last Updated - 4/11/2005)
-NOT yet FDA-approved
-a serine protease thrombolytic
-same profile as Urokinase (Abbokinase)
-1/2-Life:
-15-20 mins.
-Clearance:
-hepatic --> caution in hepatic dis.
-Dosing:
-Loading Dose --> 1000-4500 units/kg IV then
-4400 units/kg/hr continuous IV
-NOT DOC for coronary thrombolysis in Acute MI's:
A) expensive (like t-PA)
B) Lacks fibrin-specificity (like Streptokinase (Streptase)) --> systemic lytic state
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.